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A review of analytical methods for the determination of four new phosphodiesterase type 5 inhibitors in biological samples and pharmaceutical preparations BJPS
Codevilla,Cristiane Franco; Castilhos,Tamara dos Santos; Bergold,Ana Maria.
The introduction of oral phosphodiesterase type 5 inhibitor therapy in 1998 revolutionized the treatment of erectile dysfunction. Erectile dysfunction is the most common sexual problem in men. It often has a profound effect on intimate relationships and quality of life. The analysis of pharmaceuticals is an important part of the drug development process as well as for routine analysis and quality control of commercial formulations. Whereas the determination of sildenafil citrate, vardenafil and tadalafil are well documented by a variety of methods, there are few publications about the determination of udenafil, lodenafil carbonate, mirodenafil and avanafil. The paper presents a brief review of the action mechanism, adverse effects, pharmacokinetics and the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phosphodiesterase type 5 inhibitors/determination; Phosphodiesterase type 5 inhibitors/pharmaceutical preparations; Phosphodiesterase type 5 inhibitors/determination; Phosphodiesterase type 5 inhibitors/biological samples; Analytical methods; Erectile dysfunction.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100002
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Development of alternative methods for the determination of raloxifene hydrochloride in tablet dosage form BJPS
Salazar,Fernanda Rodrigues; Codevilla,Cristiane Franco; Meneghini,Leonardo; Bergold,Ana Maria.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Raloxifene/determination in tablets; High performance liquid chromatography/quantitative analysis; UV spectrophotometric method/quantitative analysis; Micellar capillary electrophoresis/ quantitative analysis; Stability-indicating methods.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200349
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Validation of a chromatographic method to routine analysis of trans-resveratrol and quercetin in red wines PAB
Silva,Letícia Flores da; Guerra,Celito Crivellaro; Czermainski,Ana Beatriz Costa; Ferrari,Leonardo; Bergold,Ana Maria.
Abstract: The objective of this work was to validate a fast method with low-solvent use, for the analysis of trans-resveratrol and quercetin in red wines. The wines were prepared, using a classical method, from the grape (Vitis vinifera) cultivars Cabernet Franc, Cabernet Sauvignon, Malbec, Merlot, Petit Verdot, Pinot Noir, Ruby Cabernet, Syrah, Tannat, and Tempranillo. Samples were filtered and analyzed by high-pressure liquid chromatography (HPLC) with a diode array detector (DAD), at 306 and 371 nm, for trans-resveratrol and quercetin, respectively. An octylsilane column was used, and the mobile phase was composed by a gradient of methanol, water, and formic acid. The method was validated according to the following figures of merit: specificity,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vitis vinifera; High-pressure liquid chromatography; Polyphenol; Quantification..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2017000500335
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